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The III-stage SURPASS series of trials showed that the highest dose group could reduce glycated hemoglobin (HbA1c) by 2.3%, while Retatrutide showed a 1.9% reduction in HbA1c in the II-stage trial for diabetic patients

[1] [2] Semaglutide is also available as Wegovy, which is the licensed product specifically for weight management in the UK

Alert the anesthesia team right away to recent GLP-1 use and GI symptoms

Piggybacking off Cleveland Clinic's stance, the benefits of GLP-1 meds are likely to outweigh the risks for individuals with type 2 diabetes and obesity and NOT for vanity-driven users who solely want to quickly drop a few pounds for an upcoming event

184 But, in a preclinical study on the DMBA-induced rat mammary carcinoma, this enhanced effectiveness of methotrexate was far outweighted by the growth-stimulating effect of 3-day pretreatment with combined insulin/glucose infusions

DOI: 10.1016/s0378-1119(96)00422-2 38