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Nrf2, a member of the capncollar family of basic regionleucine zipper transcription factors involved in transcription of antioxidant genes in response to xenobiotic stress, is also a critical regulator of cellular oxidative stress in sepsis (Kolls, 2006) and a regulator of exacerbated proinflammatory cytokine release (cytokine storm) and loss of T lymphocytes (leukopenia) that characterize the most aggressive presentation of SARS-CoV-2-mediated COVID-19 infection (Kobayashi et al., 2016

Derived from the amino acid, histidine, histamine is a bioactive amine that helps with several key cellular functions

260 Met metabolism regulates Cys and endogenous hydrogen sulfide (H 2 S) levels

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The response to this release is bronchoconstriction and vasodilation which are the general symptoms associated with asthma and various allergic reactions

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