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Furthermore, another mechanism by which this inhibition of VEGF occurs seems to be related to the destabilization of the heterodimer hypoxia-inducing factor (HIF) one alpha (HIF-1)

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Xie P, Liang Y, Liang G, Liu B

Glucose transporter-1 (GLUT-1) expression in psoriasis: correlation with disease severity

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At ~5382 Da, FOXO4-DRI is above the typical renal filtration threshold (~60 kDa for globular proteins, but much lower for linear peptides), suggesting renal clearance may contribute to elimination