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Water Reuse: Issues, Technologies, and Applications (McGraw-Hill, 2009)

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This is normal and does not indicate any problem

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These receptors sit on pancreatic beta cells, in the hypothalamus, along the vagus nerve, and in the gastrointestinal tract

(That corresponds to about 30 mL of 1% solution.) With epinephrine, the limit is higher (often up to ~7 mg/kg) due to slower absorption