This condition is often linked to lifestyle factors such as poor diet, obesity, and excessive alcohol consumption
In the absence of robust, high-quality evidence, clinical decisions should be guided by individual risk assessment and shared decision-making
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4.1.3 Inhibition of melanin synthesis by mediating MITF-related pathway It regulates the transcription of tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2), activates various target genes related to melanin synthesis, and influences the reproduction, proliferation, and survival of melanogenic cells (Wellbrock and Marais, 2005
Meanwhile, A metabolic-syndrome study reported higher energy expenditure, fatty-acid oxidation, reduced fat accumulation, and improved insulin sensitivity in mouse models
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