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A prospective randomized trial comparing metformin alone versus metformin combined with semaglutide (1 mg weekly) in 100 overweight/obese women with PCOS found that the combination therapy produced significantly greater weight loss, improved insulin resistance, decreased inflammatory markers, alleviated menstrual irregularities and increased natural pregnancy rates compared to metformin alone

Weight values larger than this cut point are trimmed

If gastrointestinal symptoms become intolerable, healthcare providers may recommend temporarily pausing dose escalation, maintaining the current dose longer before increasing, or even reducing to a previous dose until symptoms improve

Food moves more slowly from the stomach into the intestines, which helps you feel full longer and supports appetite control

Lipid peroxidation: mechanisms, inhibition, and biological effects

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