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Results, published in September 2025 in The New England Journal of Medicine , show that high-dose oral semaglutide tablets (25 mg) led to an average weight loss of about 1417% over a little more than a year , along with additional benefits like lower blood pressure and reduced inflammation

Although no formal drug-interaction studies exist in this context, caution is warranted

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And while these tend to be mild and temporary for most patients, its important to know about them, especially if you have preexisting health conditions