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Faster Weight Loss Can Come With Tradeoffs Losing weight quickly may sound ideal, but aggressive weight loss can sometimes increase the risk of: fatigue, muscle loss, loose skin, nutritional deficiencies, lower energy levels, and difficulty maintaining results long term

2B), which aligns with findings that GLP-1R agonist use is associated with an increased risk of kidney cancer (HR 1.54

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A meta-analysis of five RCTs (over 4,400 people) in Endocrinology, Diabetes & Metabolism found that GI side effects were significantly more common at orforglipron doses of 12 mg or higher

Altogether, about 1 in 8 US adults say they're currently taking one of the medicines, according to data from health policy research group KFF