The safety of long-term concurrent use has not been evaluated
A preliminary study of eleven consecutive patients evaluated individuals suffering from diabetic peripheral neuropathy who were treated with a combination of L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate (active Vitamin B6)
PMID: 26828517
If you let it go for too long, it can cause problems in your nervous system such as: Vision problems Memory loss A pricking or numbing sensation Difficulty speaking or walking due to ataxia (loss of physical coordination) Damage to your extremities (hands, feet, arms, etc.), particularly your legs Other problems could include Infertility (this should go away with B12 treatment) Stomach cancer Bleeding and infections Damage your heart, brain, bones, and other organs in your body If you're pregnant and don't get enough vitamin B12, your baby is at risk of a serious birth defect called a neural tube defect
Sakiyama, H
These effects can include swelling or redness at the injection site, itching, or mild diarrhea
