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[PubMed ID: 32348225]

Breakthroughs in disease diagnosis (i.e

FOXO4-DRI releases p53 from this inhibitory interaction, enabling activation of downstream genes involved in mitochondrial apoptosis pathways

Chronic cerebral hypoperfusion induces microglial activation, polarized toward M1 (pro-inflammatory) phenotype, and the drug fingolimod has been shown, in an animal model, to attenuate such microglia-mediated neuroinflammation and to promote oligodendrocytogenesis by shifting microglia toward M2 subtype (217)