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For lactating mothers, understanding these predispositions can help your provider weigh the relevance of GLP-1 therapy against alternative weight management strategies that carry clearer safety profiles during breastfeeding

Patients with a history of pancreatitis, symptomatic gallbladder disease, or severe gastroparesis warrant careful discussion as well, since GLP-1s slow gastric emptying and can exacerbate these conditions

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These include: Nausea : This is the most common side effect, affecting approximately 20-40% of patients initially

Open questions that need head-to-head trials Several important research questions remain: Head-to-head trials