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SIRT1 deficiency in aging microglia contributes to aging- or tau-mediated memory deficits by upregulating IL-1 through promoter-specific hypomethylation (Cho et al., 2015)

Finally, our recent work has shown that modulation of the membrane potential, through the closure of background potassium channels, systematically generates facilitating effects on the exocytosis of hormones and neurotransmitters as well as on the activation of survival pathways (Figure 4)

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