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Improved Life Expectancy Tirzepatide and semaglutide have consistently reduced risk for all-cause mortality in large, randomized placebo-controlled trials (RCT) and meta-analyses

10.1016/j.jaut.2023.103001 91 LinS.WangS.ZhangZ.LuY.YangM.ChenP.et al (2020)

Kocher HM, Steward M, Leather AJ, Cullen PT

Dose increases occur over weeks, allowing steady digestive adaptation and predictable progression

Consequently, dose titration is slow and dependent on AEs, and common recommendations like reduction on food quantity or high fat or spicy food is always suggested (151, 154, 158) Also, some hypotheses might suggest that GLP-1 stimulation can affect taste perception, as it has been reported by the FDA Adverse Event Reporting System (FAERS)