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doi: 10.1016/S0021-9258(18)67324-7 18 OrskovCHolstJJKnuhtsenSBaldisseraFGPoulsenSSNielsenOV

Studies report that the PBPK model can be applied to predict the course of all parent substances, metabolites, and some biomarkers in the studied organism, incorporating mechanistic data related with the absorption, distribution, metabolism, and excretion (ADME) properties [134,135,136,137]