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Specificity analyses also consistently indicated significant associations between GLP-1 RAs use and reduced risks in different composite adverse outcomes, further substantiating the robustness of our results (Figure S4)

Anti-Obesity Therapy: From Rainbow Pills to Polyagonists

doi: 10.1126/scitranslmed.aat3392 69 KimSJNianCKarunakaranSCleeSMIsalesCMMcIntoshCH

This is the core pharmacological rationale for the triple agonist design

Unlike opioid medications, it works at peripheral pain receptors and, therefore, is not associated with CNS adverse effects

For some patients, these medications may offer benefits that extend beyond blood sugar control, particularly in optimizing conditions that support reproductive health