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Experimental procedures included surgery models such as subdiaphragmatic vagal deafferentation (SDA), specific ablation of the area postrema (AP), and paraventricular nucleus (PVN) lesions, all of which were conducted on Sprague-Dawley (SPDR) rats

These include monogenic , diet-induced , and single- or multi-target humanized models targeting appetite regulation, incretin signaling, and metabolic pathways, providing invaluable tools for advanced preclinical research and drug discovery

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Could Mounjaro be the better option for managing type 2 diabetes and weight loss Compared to other GLP-1s, how does Mounjaro compare for people with type 2 diabetes

Tirzepatide is the clinical exemplar