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Hexosamine pathway Excess glucose not metabolized via glycolysis can enter the hexosamine pathway, which leads to increased production of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), which is used for O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins

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(d) elevated systolic blood pressure equal to or greater than 130 or elevated diastolic blood pressure equal to or greater than 85 or on drug therapy for hypertension, (e) elevated fasting glucose level equal to or greater than 100 mg/dL or on drug therapy for hyperglycemia/diabetes)

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But theory and practice do not always align

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