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Methionine is an essential proteinogenic amino acid and also the precursor of S-adenosylmethionine (SAM), the universal reactive methyl donor in biochemical reactions (Kharbanda et al., 2005)

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Cancer cells must maintain metabolic homeostasis in a wide range of conditions, including harsh microenvironments in which cancer cells must continue to meet the high bio-energetic demand in order to undergo replication 1

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