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For those already on a GLP-1 and worried about experiencing the inevitable shed, the first thing to do is remember that this is a normal side effect (to a degree) and it doesnt mean you should abandon ship on your GLP-1

Providers typically recommend that patients choose a time they can reliably maintain, as missed doses or irregular administration can compromise glycemic control and weight management outcomes

Diabetes Care, 42 (9), 1595-1603

Research shows no major reduction in gastric motility with any agonists after 4-6 weeks [24]

This pattern mirrors whats seen in other chronic conditions, where relapses occur once treatment stops

In our study, the expression of PINK1 and Parkin was increased in a high glucose condition