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Key considerations include: Patient Access and Equity: Limited coverage under pharmacy benefits means many patients (especially obese patients without diabetes) lack access to effective treatment

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Therefore, we investigated the possible mechanism of GLP-1RA action on tumors based on the results of existing studies

At microdose levels, this risk is likely minimal, but patients with existing gallbladder disease should be monitored

Patients are randomized in parallel fashion to subcutaneous tirzepatide once weekly or matching placebo

0.052 0.004%, p = 0.03