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When stored at -20C, the active ingredients will remain effective for at least 2 months, but the integrity of the liposomes may be damaged when frozen for more than 2 months

It may take weeks for some people, and most start seeing the benefits after four to six months

The chemical name is -(5,6-dimethylbenzimidazoly) hydroxocobamide

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2011 May;178(5):2032-43

Interestingly, the aryl hydrocarbon receptor (AhR) of the tryptophan-kynurenine pathway serves as a critically important mediator between tryptophan metabolism, immune reactions, and tissue homeostasis (4143), and several kynurenine metabolites have been associated with fatigue (44, 45)