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Wong WY, et al

Other research has focused on genetic and biochemical factors

Our cases did not show an alarming evolution, but a course of months, clinically more compatible with a benign pigmented lesion

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[144] [143] [157] Since both natural rewards and addictive drugs induce the expression of FosB (i.e., they cause the brain to produce more of it), chronic acquisition of these rewards can result in a similar pathological state of addiction