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The World Health Organization (WHO) defines both overweight and obesity as abnormal or excessive fat accumulation that presents a risk to health

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Both the liver and skeletal muscle have the greatest propensity for glucose uptake and glycogen storage, where GLP-1 signaling is seen to increase glycogen synthesis in these tissues

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Taken together, the results emphasize the complexity of GLP-1R signaling across different cancer types and suggest that the effects of GLP-1 receptor activation may vary widely depending on the specific tumor biology

The precise step sizes and timings varied by protocol arm