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The mechanism of action of semaglutide and tirzepatide relies on their precise three-dimensional structure to mimic endogenous GLP-1 and, in the case of tirzepatide, glucose-dependent insulinotropic polypeptide (GIP)

Moreover, some patients may interrupt their treatment once symptoms improve, not realising the long-term necessity of ongoing supplementation to prevent recurrence of deficiency symptoms

It underscores why the CagriSema vs retatrutide debate remains active

We always start the lowest dose and then every month, as long as the patient is tolerating or not having severe side effects, we go up on that dose

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CMS is committed to ensuring that policies do not inadvertently limit access to essential healthcare services or impose undue burdens on providers and suppliers