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SCFAs, such as acetate (C 2 ), propionate (C 3 ), and butyrate (C 4 ), are critical for epithelial barrier integrity, and anti-inflammatory signaling.Low levels are associated with IBD, cancer, obesity, diabetes, kidney disease, hypertension, liver disease, immune system dysfunction, and neurocognitive conditions
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In nonsegmental vitiligo, systemic immune activation occurs, whereas in the segmental type, there is only a localized cytotoxic reaction, probably due to melanocyte mosaicism.93 Tregs are unaffected in the peripheral blood of segmental vitiligo when compared to controls
