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Abdominal Pain : Severe, persistent abdominal pain, especially if radiating to the back and accompanied by vomiting, requires immediate medical attention as it may indicate pancreatitis, a rare but serious adverse effect noted in FDA warnings

GLP-1 Medications and IBS Symptom Overlap Common side effects of GLP-1 therapynausea, constipation, diarrhea, and abdominal discomfortcan mimic or worsen existing IBS symptoms, making it difficult to distinguish between medication effects and disease activity

Most sleep changes improve as the body adjusts

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Nevertheless, current evidence remains limited, and large-scale, well-controlled studies with adequate confounder adjustment are needed to substantiate this association more definitively

This step is important because semaglutide is absorbed poorly if taken incorrectly