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Fineman MS, Bicsak TA, Shen LZ, et al

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The uptick in NAION-related lawsuits follows the publication of a June 2025 study in JAMA Ophthalmology , which found a significant association between semaglutide use and increased risk of optic nerve damage

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The brain is also a major site of Mn deposition, with regional concentrations ranging from 0.16 to 0.46 mg/kg, the highest levels found in the globus pallidus and putamen, regions primarily responsible for motor control (Krebs et al., 2014)