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2014 Oct 17;7:267-74.

They are commoner in females and non-smokers, usually appear first in childhood and tend to reduce in number and frequency before age 40

Unlike traditional GERD, LPR often occurs without any noticeable chest burning

Minimize time at room temperature before using to avoid moisture during handling

Lastly, there are some cases as well that the capsule melt due to hot temperature or above 20 degrees by its active ingredients it only means that this is too much of active ingredients that the excipients ( or what we called starch, rice brand , magnesium stearate are not enough) well do not be worry, if the powder is white it means that the ingredients are in the highest quality however if the powder becomes yellow then it means its already oxidized or useless