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So, C57BL/6N mice appear to be a better model for the redox changes that occur with human brain aging than C57BL/6J mice

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Weight regain is common after cessation of pharmacotherapy

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The finding that GCLc- or GSS-deficient mice are non-viable in the embryonic period [35,36], while GCLm-deficient mice are viable and fertile with decreased GSH levels in the tissues compared to those of wild-type mice [37], suggest that GSH is essential for embryogenesis