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In the axonal loss, which is considered to be the main cause of permanent clinical disability in MS, key elements are inflammation, mitochondrial alteration, upregulation of sodium channels and glutamate excitotoxicity
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Combined with the fact that semaglutide already has approval for use in Type 2 diabetes mellitus and a good safety record, there is potential for semaglutide and other GLP-1R agonists to be repurposed as neuroprotective therapeutic agents