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We propose that the requirement of two distinct glutathione interaction sites for the efficient reduction of glutathionylated disulfide substrates explains the deviating structurefunction relationships, activities and substrate preferences of different glutaredoxin subfamilies as well as thioredoxins

However, treatment with 15M CUR and 15M Nano-BLK, but not 15M Nano-CUR, resulted in decreased islet cell viability (10010.5 vs 56.66.6 vs 59.47.4 vs 72.82.5, n=6, P=0.01, 0.02 and 0.32)

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doi:10.1371/journal.pone.0273364 Fang, J., Chen, W., Hou, P., Liu, Z., Zuo, M., Liu, S., Feng, C., Han, Y., Li, P., Shi, Y., & Shao, C