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doi: 10.3389/fphar.2025.1638645 Received 09 June 2025 Accepted 28 July 2025 Published 22 August 2025 Volume 16 - 2025 Edited by Maria Luisa Soto-Montenegro, Instituto de Investigacin Sanitaria Gregorio Maran, Spain Reviewed by Vivek P

(5) In the management of diabetes (including newly diagnosed type 2 diabetes), insulin therapy should be initiated as early as possible if there is significant unexplained weight loss[1]

The enzyme CSE catalyzes the synthesis of cysteine from cystathionine, and its promoter contains a binding site for Nrf2, and expression can be triggered by oxidative stress (199)

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