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2013;5 doi: 10.1126/scitranslmed.3007218

After further adjustment for major risk factors of fractures (age, weight or bone mineral density, fracture history, smoking status, calcium intake and sex hormone binding globulin), lower testosterone was still associated with increased risk of fracture, particularly with hip and non-vertebral fractures. Although low levels of estradiol and testosterone were associated with a higher risk of fracture in men over 60, only the effect of testosterone was independent of other risk factors , the authors conclude