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Thirdly, patients with Down syndrome or autism have increased oxidative stress and exhibit particular disturbed profiles of one-carbon metabolism [1315]

Further, NAD + is a potent activator of sirtuins, which are conserved multifunctional regulators of aging and age-related diseases in various model organisms from yeast to mammals [9092]

& Grant, S

6A, Supplementary Fig

In addition, the one of the effective substances -asarone of VOA can affect the endogenous corticosterone levels in the central nervous system by regulating the hypothalamus-pituitary-adrenal axis, thereby regulating behaviour and neurochemical reactions (Lee et al., 2014)

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