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This effect was abolished in mice lacking GLP-1R expression in T cells, demonstrating a central role for T cell GLP-1R signaling in mediating the anti-inflammatory actions of GLP-1RAs

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Tonum cites human clinical trial data reporting about a 10.4% average weight loss over six months and notes that most of the loss was fat rather than lean mass

The animals were housed under standard laboratory conditions, with a temperature of 25 C, a 12 h light/dark cycle, and humidity levels typically maintained at 50%