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Working with mouse models, a research team from Michigan State University concluded that reducing levels of the antioxidant glutathione (GSH) may help to protect the colon from inflammatory induced damage from colitis

It is prolonged, cumulative exposure that causes measurable degradation

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The neuronal loss and atrophy were particularly evident in the CA1 region of the hippocampus and layers II-III of the cerebral cortex

93, 94 Recent clinical data also indicates that variants of GTP cyclohydrolase I are governing NO production, autonomic activity and even cardiovascular risk

That criticism is not the entire story