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A., Walaszczyk, A., Spyridopoulos, I., Dookun, E

15-HpETE-PE is catalyzed by the 15-lipoxygenase (15-LOX), which is encoded by Alox5 gene and can oxygenate polyunsaturated fatty acids to lipid peroxides (71)

2021;23(Suppl 3):529

This is not simply a tolerability story it reflects an intersection of side-effect burden, inadequate weight loss response, access barriers, and cost that together create a real-world efficacy gap between what randomized controlled trials demonstrate and what clinicians observe in practice