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Future studies should consider the different forms of cell death, whether they act simultaneously or successively through interactions, and whether any one of these cell death pathways plays a predominant role

Although the exact mechanisms by which the coordinated actions of GLP-1 receptor agonism and NMDA receptor antagonism correct metabolic diseases await further elucidation, the extensive alterations in transcriptomic and proteomic responses within the hypothalamus, linked to glutamatergic signalling and synaptic plasticity, imply that the conjugate might elicit neurostructural changes in GLP-1-receptor-expressing neurons

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Int J Dev Neurosci 27(4):377383

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Arch Insect Biochem Physiol