Silva, Patrcia Severino, Eliana B
It is widely recognized that oxidative stress and the production of ROS have the potential to hinder mitochondrial activity 110 , leading to the suppression of STAR gene expression
F., Rajagopal, P., Jayaraman, S., et al
By binding to cardiolipin, Elamipretide stabilizes mitochondrial cristae, improves membrane integrity, and enhances oxidative phosphorylation (Minkler et al., 2015)
However, the clinical significance of TMAO generation from L-carnitine supplementation in humans remains under active investigation, and there is currently no official regulatory warning from the MHRA or EMA specifically prohibiting its use on these grounds
However, both groups experienced similar levels of weight loss (3.24 vs