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The pH of the vagina also changes with decreased estrogen, increasing the risk of infections or urinary leakage

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Patients who combine GLP-1 therapy with dietary changes and increased physical activity typically experience faster and more significant weight loss than those relying on medication alone

The findings on orforglipron come from ATTAIN-MAINTAIN, a first-of-its-kind phase 3 trial conducted by the GLP-1 drugmaker Eli Lilly, which manufactures Zepbound and is developing the new oral medication

Rotating spots gives each patch of tissue time to recover, so injection site reactions stay mild and rare