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doi:10.1007/s40265-022-01676-5
Thiamine (B1) is pivotal in carbohydrate metabolism and neuronal energy production
doi:10.1089/jmf.2019.0320 102
PA: Project administration, Writing review and editing, Conceptualization, Supervision
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The combination's popularity is based on the complementary nature of their individually studied mechanisms
More recently, it has been demonstrated that NSC-34 cells expressing TDP-43 mutants also exhibit shortened neurites, increased OS, and decreased HO1 level, and these effects can be reversed by the UPS inhibitor MG132, but not by the Nrf2 activator sulforaphane [255, 256], probably because MG132 induction of HO1 is Nrf2 independent
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