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This action promotes the firing of layer V pyramidal neurons and stimulates glutamate release ( 5.1.2 Impact on neurotransmitters and synaptic plasticity Chronic ketamine use disrupts the balance between excitatory and inhibitory neurotransmission

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These findings provide a solid mechanistic foundation for the future development of BPC157-based or sequential therapeutic agents targeted at enhancing vascular repair

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Eluted proteins were concentrated using an Amicon Ultra-15 Centrifugal Filter Unit (10 kDa cutoff) and further purified by size exclusion chromatography on a Superdex 200 Increase 10/300 gel filtration column (Cytivia 28990944) in TBS buffer

doi: 10.1016/s0092-8674(00)80405-5