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Notch activation enhances mesenchymal stem cell sheet osteogenic potential by inhibition of cellular senescence

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This equates to 2.4mg for each dose, up to 4.8mg daily [14]

Blood sugar can remain normal for years before a problem is detected

The estimated oral dose range from animal research is approximately 18 mg/kg, but human pharmacokinetic parameters including bioavailability fraction, Tmax, and clearance remain entirely unknown

10.1146/annurev-clinpsy-050817-084811 43 HashemiM