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Alpern RJ, Sakhaee K

Researchers dont know precisely why semaglutide and constipation can often go hand-in-hand, but they theorize its related to how the medication works on your digestive system: It slows your digestion: Semaglutide is a glucagon-like peptide-1 receptor ( GLP-1 ) agonist that delays gastric emptying the movement of food from your stomach into your intestines

Reddy et al., 2014

10.3390/antiox12111965 109 KrishnamurthyH

Imodium (Loperamide) uses There is one FDA-approved use for Imodium, but physicians may also use it off-label to treat other conditions