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Moreover, iPLA2, a member of the calcium-independent phospholipase A2 family, functions independently of glutathione by cleaving oxidized fatty acid chains from phospholipids, directly removing peroxidized products, effectively detoxifying damaged lipids, and maintaining membrane integrity ( In summary, lipid peroxidation is central in ferroptosis, driven by ROS-mediated oxidative damage to PUFAs in cellular membranes

SunYZhengYWangCLiuY.Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

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Cathelicidin, an antimicrobial peptide produced by macrophages, promotes colon cancer by activating the Wnt/-catenin pathway

Proc Natl Acad Sci U S A , 110 (52), 2100621011

Circulation 2024;150:1781-90.ArticlePubMed 120