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It was engineered in the 1990s at Monash University in Australia by a research group led by Frank Ng, with a very specific hypothesis: that the fat-mobilizing actions of growth hormone could be isolated from its other metabolic effects if you stripped the molecule down to the relevant fragment

Clinicians usually start GLP-1s at a low dose to avoid nausea and other side effects, then slowly increase the dose every 1 to 4 weeks based on your tolerance and blood sugar response