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Abnormal accumulation or deficiency of trace elements plays a significant role in cancer pathogenesis and progression, with dysregulation of copper metabolism being particularly notable (143,144)

Dual Inhibition of MDM2 and XPO1 Induces Synergistic Apoptosis in Wild-type p53 Acute Myeloid Leukemia through Nuclear Accumulation of p53 and Suppression of c-Myc

Athletic Therapy Today , 14 (6), 3337

Meanwhile, astrocytes are also activated in response to inflammation, influencing synaptic transmission efficiency by regulating both neuronal energy metabolism and clearance of glutamate (151)

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimers disease