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doi: 10.3390/diseases7010021 69 JeongJ.SprickJ

1.2.1 The main issue is optimization of drug bioavailability The main issue for any formulation of niclosamide (and indeed other BCS Class II and IV low water-solubility drugs) is how to optimize local bioavailability

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Results: In patients undergoing EVT, 25.0% demonstrated increased DWI-ASPECTS and 32.0% had reduced DWI-volume, both strongly linked to favorable outcomes (three-month mRS 2) with odds ratios of 4.90 and 5.60 (95% CIs: 1.6614.46 and 2.0914.98)

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