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A positive rather than a negative role for DHT in the maintenance of penile ARs would be more in agreement with the fact that this compound is essential for penile embryologic development.11 So far, the evidence for the presence of androgen-responsive elements in the rat androgen receptor promoter is weak,18 but this does not rule out an indirect positive role of DHT through other pathways

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In European-ancestry populations, the expected double null frequency under independence is approximately 510%

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