Success is monitored, risks are transparent, but side effects are brutal and some patients quit because they feel awful
For some, this creates a cycle of reliance, anxiety, or shamefueling the very stigma these medications claim to solve
The one letdown is tracking
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Smaller trials and animal studies had suggested that GLP-1s might help slow cognitive decline or reduce neuro-inflammation, but larger trials like Novos were needed to confirm whether patients saw actual benefits
109 Early and late endosome shrinkage and fission are among the factors that control the trafficking of cargo from late endosomes to the Golgi, which is spatiotemporally associated with ER contact sites